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KMID : 0361020100530070399
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Korean Journal of Otolaryngology - Head and Neck Surgery
2010 Volume.53 No. 7 p.399 ~ p.407
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Na+ Homeostasis in the Inner Ear
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Kim Sung-Huhn
Kim Sang-Cheol
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Abstract
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Na+ homeostasis in the inner ear is important to maintain normal hearing and balance. Na+ transport in the inner ear is reported to be occurred in non-sensory epithelium of inner ear which forms a barrier between endolymphatic space and perilymphatic space. Functionally identified and constitutively active Na+ absorption sites in the inner ear are Reissner’s membrane, outer sulcus cells, vestibular transitional cells, saccular nonsensory epithelial cells, and endolymphatic sac epithelial cells. Na+ transport in these epithelial cells is mediated by apically located epithelial Na+ channels (ENaC), nonselective cation channels and basolaterally located Na+, K+-ATPase. Na+ absorption is increased by glucocorticoid through glucocorticoid receptor or ATP through purinergic receptors depending on cell types.
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KEYWORD
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Sodium, Homeostasis, Inner ear, Cochlear, Vestibule, Endolymphatic sac
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